scPDB - Distribution of Binding site Similarity values of 1rf7 entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1rf7	DHF	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	1.000
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.598
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.585
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.583
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.555
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.551
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.544
5hi6	MTX	Dihydrofolate reductase	/	0.544
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.542
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.529
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.529
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.529
1jom	FFO	Dihydrofolate reductase	1.5.1.3	0.528
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.525
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.525
4i1n	FOL	Dihydrofolate reductase	1.5.1.3	0.524
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.523
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.521
1rx7	FOL	Dihydrofolate reductase	1.5.1.3	0.519
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.516
5cc9	DDF	Dihydrofolate reductase	1.5.1.3	0.507
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.506
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.498
1rx5	DDF	Dihydrofolate reductase	1.5.1.3	0.498
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.496
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.495
4x5i	FOL	Dihydrofolate reductase	1.5.1.3	0.487
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.484
4elb	34S	Dihydrofolate reductase	/	0.480
4ele	31I	Dihydrofolate reductase	/	0.471
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.468
3fl8	RAR	Dihydrofolate reductase	/	0.466
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	0.462
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.459
1rx4	DDF	Dihydrofolate reductase	1.5.1.3	0.458
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.455
4qi9	MTX	Dihydrofolate reductase	/	0.455
2qk8	MTX	Dihydrofolate reductase	/	0.451
4i13	FOL	Dihydrofolate reductase	1.5.1.3	0.451
1rx8	FOL	Dihydrofolate reductase	1.5.1.3	0.446
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.446
4elg	52J	Dihydrofolate reductase	/	0.446
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.445
1rx6	DDF	Dihydrofolate reductase	1.5.1.3	0.443
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.442
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.441
4bii	PYW	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.440