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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1r1iTI1Neprilysin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1r1iTI1Neprilysin/1.000
1r1jOIRNeprilysin/0.610
4zr5RDFNeprilysin/0.557
4cthRDFNeprilysin/0.542
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.514
2re8GSUGlutamine--tRNA ligase6.1.1.180.473
4k88HFGBifunctional glutamate/proline--tRNA ligase6.1.1.150.472
4xba5GPAprataxin-like protein30.470
4mvcCDCCholine-phosphate cytidylyltransferase A/0.463
2aouCQAHistamine N-methyltransferase2.1.1.80.459
3dwbRDFEndothelin-converting enzyme 13.4.24.710.458
1n0sFLUBilin-binding protein/0.454
3r1rATPRibonucleoside-diphosphate reductase 1 subunit alpha1.17.4.10.453
1nj5P5AProline--tRNA ligase/0.451
2anb5GPGuanylate kinase2.7.4.80.451
2z95NDPGDP-mannose 4,6-dehydratase/0.451
3nh8DC2N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)3.5.1.1140.451
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.451
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
1ex75GPGuanylate kinase2.7.4.80.447
1vbiNADMalate/L-lactate dehydrogenase family protein/0.447
3af1GDPPantothenate kinase2.7.1.330.446
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.445
1ogjFADFerredoxin--NADP reductase1.18.1.20.444
3dr4G4MGDP-perosamine synthase/0.444
5c3rHMUThymine dioxygenase/0.444
4qak2AMRNA 2',3'-cyclic phosphodiesterase/0.443
1gky5GPGuanylate kinase2.7.4.80.442
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.441
1yw8A75Methionine aminopeptidase 2/0.441
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.441
4bqzGNPEctonucleoside triphosphate diphosphohydrolase 2/0.441
1x1aSAMC-20 methyltransferase/0.440
3e6eDCSAlanine racemase/0.440
4a7zAY9Aldos-2-ulose dehydratase/0.440