sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1mzs | 669 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1mzs | 669 | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 1.000 | |
| 1hnj | MLC | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | / | 0.500 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.487 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.477 | |
| 1aa6 | MGD | Formate dehydrogenase H | 1.1.99.33 | 0.467 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.463 | |
| 3zxs | FAD | Deoxyribodipyrimidine photolyase-related protein | / | 0.463 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.462 | |
| 4dja | FAD | (6-4) photolyase | / | 0.456 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.455 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.455 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.454 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.452 | |
| 3w6u | NAP | 6-phosphogluconate dehydrogenase, NAD-binding protein | / | 0.452 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.451 | |
| 3iwj | NAD | Aminoaldehyde dehydrogenase | / | 0.451 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.448 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.447 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.446 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.442 | |
| 1osv | CHC | Bile acid receptor | / | 0.442 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.442 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.442 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.442 | |
| 4d03 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 4wso | NAD | Probable nicotinate-nucleotide adenylyltransferase | / | 0.442 | |
| 5a01 | 12V | O-glycosyltransferase | / | 0.442 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.441 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2cdu | FAD | NADH oxidase | / | 0.440 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 4y9u | NAP | NADPH--cytochrome P450 reductase | / | 0.440 |