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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1me6IVSPlasmepsin-23.4.23.39

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1me6IVSPlasmepsin-23.4.23.391.000
1xe55FEPlasmepsin-23.4.23.390.594
1w6hTITPlasmepsin-23.4.23.390.563
1lf3EH5Plasmepsin-23.4.23.390.491
1psa0ZLPepsin A3.4.23.10.480
1xe65FPPlasmepsin-23.4.23.390.475
2vkmBSDBeta-secretase 13.4.23.460.470
3own3OXRenin3.4.23.150.464
1lf2R37Plasmepsin-23.4.23.390.462
1bim0QBRenin3.4.23.150.461
1fm4DXCMajor pollen allergen Bet v 1-L/0.461
2is0I03Beta-secretase 13.4.23.460.461
3lpkZ76Beta-secretase 13.4.23.460.458
3ixj586Beta-secretase 13.4.23.460.455
3d91REMRenin3.4.23.150.452
4a84DXCMajor pollen allergen Bet v 1-A/0.452
2b8l5HABeta-secretase 13.4.23.460.450
2qzlIXSBeta-secretase 13.4.23.460.450
2p4j23IBeta-secretase 13.4.23.460.447
2zjmF1MBeta-secretase 13.4.23.460.447
2p83MR0Beta-secretase 13.4.23.460.446
3cid318Beta-secretase 13.4.23.460.446
3cic316Beta-secretase 13.4.23.460.443
2g1s4IGRenin3.4.23.150.442
2ph6712Beta-secretase 13.4.23.460.442
3dm6757Beta-secretase 13.4.23.460.442
4dpf0LGBeta-secretase 13.4.23.460.442
4q71FADBifunctional protein PutA/0.442
3lpiZ74Beta-secretase 13.4.23.460.440
3vswR31Renin3.4.23.150.440