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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ltzHBIPhenylalanine-4-hydroxylase1.14.16.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ltzHBIPhenylalanine-4-hydroxylase1.14.16.11.000
1lrmHBIPhenylalanine-4-hydroxylase1.14.16.10.498
2tohHBITyrosine 3-monooxygenase1.14.16.20.496
3c34KAIGlutamate receptor ionotropic, kainate 1/0.492
1qzzSAMAclacinomycin 10-hydroxylase RdmB4.1.10.480
3c36KAIGlutamate receptor ionotropic, kainate 1/0.472
3c35KAIGlutamate receptor ionotropic, kainate 1/0.462
4gxs0YSGlutamate receptor 2/0.456
3b7dCNIGlutamate receptor 2/0.455
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.455
1j8uH4BPhenylalanine-4-hydroxylase1.14.16.10.450
3upyFOMOxidoreductase, putative/0.449
1dmwHBIPhenylalanine-4-hydroxylase1.14.16.10.447
1r00SAHAclacinomycin 10-hydroxylase RdmB4.1.10.447
3h03UBPGlutamate receptor 2/0.447
3lpfZ77Beta-glucuronidase3.2.1.310.447
4f1yCNIGlutamate receptor 3/0.447
1z5uCMPClass B acid phosphatase/0.446
2nnqT4BFatty acid-binding protein, adipocyte/0.446
2pbwDOQGlutamate receptor ionotropic, kainate 1/0.446
4l17DNQGlutamate receptor 2/0.446
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.446
3nj0PYVAbscisic acid receptor PYL2/0.445
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.444
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.443
1ftlDNQGlutamate receptor 2/0.442
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2vn1FK5Peptidylprolyl isomerase/0.442
3hv3R49Mitogen-activated protein kinase 14/0.442
4h8i11WGlutamate receptor ionotropic, kainate 2/0.441
2d2gDZZPhosphotriesterase/0.440
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.440