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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1kuyCOTSerotonin N-acetyltransferase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1kuyCOTSerotonin N-acetyltransferase/1.000
1l0cCOTSerotonin N-acetyltransferase/0.696
1cjwCOTSerotonin N-acetyltransferase/0.648
1kuxCA3Serotonin N-acetyltransferase/0.619
1kuvCA5Serotonin N-acetyltransferase/0.571
1ib1COTSerotonin N-acetyltransferase/0.497
3a1l2CCCytochrome P450/0.470
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
3g86T18Genome polyprotein2.7.7.480.452
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.447
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.447
3pqbVGPPutative oxidoreductase/0.445
5dp2NAPCurF/0.445
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.442
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.441
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.441
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441