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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1jstATPCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1jstATPCyclin-dependent kinase 22.7.11.221.000
1qmzATPCyclin-dependent kinase 22.7.11.220.567
4ii5ADPCyclin-dependent kinase 22.7.11.220.502
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.498
4eooATPCyclin-dependent kinase 22.7.11.220.495
2cjmATPCyclin-dependent kinase 22.7.11.220.494
3bu5ATPInsulin receptor2.7.10.10.494
4qnyANPMitogen activated protein kinase, putative/0.493
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.476
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.473
4ix5ANPUncharacterized protein/0.473
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.471
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.470
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.468
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.464
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.458
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.458
5dosATPAurora kinase A2.7.11.10.455
5dnrATPAurora kinase A2.7.11.10.453
1ig1ANPDeath-associated protein kinase 12.7.11.10.444
4gt3ATPMitogen-activated protein kinase 12.7.11.240.444
4ysjADPCalmodulin-like domain protein kinase/0.444
1b38ATPCyclin-dependent kinase 22.7.11.220.440
4deeADPAurora kinase A2.7.11.10.440