scPDB - Distribution of Binding site Similarity values of 1jol entry / Site 2

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1jol	FFO	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1jol	FFO	Dihydrofolate reductase	1.5.1.3	1.000
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.669
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.654
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.633
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.618
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.601
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.587
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.564
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.550
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.545
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.535
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.514
5hi6	MTX	Dihydrofolate reductase	/	0.509
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.508
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.504
1dyi	FOL	Dihydrofolate reductase	1.5.1.3	0.501
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.501
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.496
1dyh	DZF	Dihydrofolate reductase	1.5.1.3	0.489
4x5i	FOL	Dihydrofolate reductase	1.5.1.3	0.471
1rb2	FOL	Dihydrofolate reductase	1.5.1.3	0.468
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.468
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.460
4ele	31I	Dihydrofolate reductase	/	0.444
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.440
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.440