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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1j1bANPGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1j1bANPGlycogen synthase kinase-3 beta2.7.11.261.000
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.584
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.508
4j95ACPFibroblast growth factor receptor 2/0.459
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.455
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.454
4fv6E57Mitogen-activated protein kinase 12.7.11.240.453
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.444
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440