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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.62

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.621.000
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.636
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.494
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.487
4bfxZVXPantothenate kinase2.7.1.330.467
4q71FADBifunctional protein PutA/0.467
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.465
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.465
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.457
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.454
5hs1VORLanosterol 14-alpha demethylase/0.454
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.448
3gw9VNILanosterol 14-alpha-demethylase/0.445
4g7gVFVLanosterol 14-alpha-demethylase/0.445
1bim0QBRenin3.4.23.150.443
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
4g3jVNTLanosterol 14-alpha-demethylase/0.440