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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1i44ACPInsulin receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1i44ACPInsulin receptor2.7.10.11.000
2ijmATPFocal adhesion kinase 12.7.10.20.478
4qmlANPSerine/threonine-protein kinase 242.7.11.10.461
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.459
2henADPEphrin type-B receptor 22.7.10.10.451
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.449
4c3pACPAurora kinase A2.7.11.10.449
4qnyANPMitogen activated protein kinase, putative/0.446
3kvxFMYMitogen-activated protein kinase 102.7.11.240.445
4xlvACPInsulin receptor2.7.10.10.442