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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1gerFADGlutathione reductase1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1gerFADGlutathione reductase1.8.1.71.000
1geuFADGlutathione reductase1.8.1.70.700
1getFADGlutathione reductase1.8.1.70.609
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.568
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.564
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.558
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.554
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.552
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.543
1grhFADGlutathione reductase, mitochondrial1.8.1.70.540
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.537
1greFADGlutathione reductase, mitochondrial1.8.1.70.535
1grgFADGlutathione reductase, mitochondrial1.8.1.70.535
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.532
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.529
3grsFADGlutathione reductase, mitochondrial1.8.1.70.527
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.523
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.521
2v6oFADThioredoxin glutathione reductase/0.520
1febFADTrypanothione reductase1.8.1.120.519
2r9zFADGlutathione amide reductase/0.515
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.512
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.512
1graFADGlutathione reductase, mitochondrial1.8.1.70.510
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.505
1feaFADTrypanothione reductase1.8.1.120.502
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.502
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.492
1zk7FADMercuric reductase1.16.1.10.487
2eq9FADDihydrolipoyl dehydrogenase/0.486
1bzlFADTrypanothione reductase1.8.1.120.483
2rabFADGlutathione amide reductase/0.477
4jq9FADDihydrolipoyl dehydrogenase/0.476
4j56FADThioredoxin reductase 21.8.1.90.472
3ladFADDihydrolipoyl dehydrogenase/0.470
3ic9FADPutative dihydrolipoamide dehydrogenase/0.469
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.463
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.459
1zx9FADMercuric reductase1.16.1.10.455
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.454
1grbFADGlutathione reductase, mitochondrial1.8.1.70.452
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.452
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.451
3urhFADDihydrolipoyl dehydrogenase/0.451
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.451
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.448
2eq8FADDihydrolipoyl dehydrogenase/0.447
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.447
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.446
1onfFADGlutathione reductase1.8.1.70.445
2yquFADDihydrolipoyl dehydrogenase/0.442
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.440