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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1g4sTPSThiamine-phosphate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1g4sTPSThiamine-phosphate synthase/1.000
2tpsTPSThiamine-phosphate synthase/0.648
1g67TZPThiamine-phosphate synthase/0.636
1g4tFTPThiamine-phosphate synthase/0.620
1g69TZPThiamine-phosphate synthase/0.617
1g6cTZPThiamine-phosphate synthase/0.550
3nl6TPSUncharacterized protein/0.518
1g6cIFPThiamine-phosphate synthase/0.477
2nnhREACytochrome P450 2C8/0.467
3pwhZMAAdenosine receptor A2a/0.461
2hcdBIVVitamin D3 receptor A/0.460
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.459
4ktoFADPutative isovaleryl-CoA dehydrogenase protein/0.459
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4ly91YYGlucokinase regulatory protein/0.457
3pm0BHFCytochrome P450 1B1/0.456
2hb7O1CVitamin D3 receptor/0.453
3vrwYS5Vitamin D3 receptor/0.453
4nu5NADPhosphonate dehydrogenase1.20.1.10.453
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.451
4h9814QUncharacterized protein/0.448
3fhyATPPyridoxal kinase2.7.1.350.447
3o153NMThiamine-phosphate synthase/0.446
4ia3BIVVitamin D3 receptor A/0.446
4yaoFMNNADPH--cytochrome P450 reductase/0.446
2qa2FADPolyketide oxygenase CabE/0.445
4e5yNDPGDP-L-fucose synthase1.1.1.2710.445
1e3lNADAlcohol dehydrogenase 41.1.1.10.444
4dpwAGSMevalonate diphosphate decarboxylase/0.444
3w0yDS4Vitamin D3 receptor/0.443
2znnS44Peroxisome proliferator-activated receptor alpha/0.442
4xxvNAD3-isopropylmalate dehydrogenase/0.442
1m4dCOAAminoglycoside 2'-N-acetyltransferase2.3.10.441
3k9uACOSpermidine N(1)-acetyltransferase/0.441
3kpkFADSulfide-quinone reductase/0.441
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.440
2hamC33Vitamin D3 receptor/0.440
3b6zCO7Enoyl reductase LovC10.440