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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1g17GNPRas-related protein SEC4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1g17GNPRas-related protein SEC4/1.000
4lhwGNPRas-related protein Rab-8A/0.580
2gilGTPRas-related protein Rab-6A/0.574
3a58GNPGTP-binding protein RHO1/0.571
4nyjGNPGTPase HRas/0.564
4nyiGNPGTPase HRas/0.562
3lbnGNPGTPase HRas/0.560
1zbdGTPRas-related protein Rab-3A/0.557
3e5hGNPRas-related protein Rab-28/0.557
3oesGNPGTPase RhebL1/0.551
1yzqGNPRas-related protein Rab-6A/0.550
1cxzGSPTransforming protein RhoA/0.549
1zc3GNPRas-related protein Ral-A/0.549
4dltGNPGTPase HRas/0.545
3rabGNPRas-related protein Rab-3A/0.543
5dhaGNPGTP-binding nuclear protein Ran/0.543
3bbpGTPRas-related protein Rab-6A/0.542
4qxaGTPRas-related protein Rab-9A/0.542
5jljGNPGTP-binding nuclear protein Ran/0.542
3w3zGTPGTP-binding nuclear protein Ran/0.538
1kmqGNPTransforming protein RhoA/0.536
1xtsGTPGTP-binding protein Rheb/0.536
3nbzGTPGTP-binding nuclear protein Ran/0.533
4xoiGTPTransforming protein RhoA/0.533
1zc4GNPRas-related protein Ral-A/0.532
4k81GTPGTPase HRas/0.530
3bc1GNPRas-related protein Rab-27A/0.528
3ea5GDPGTP-binding nuclear protein Ran/0.528
3i3sGNPGTPase HRas/0.527
1t91GTPRas-related protein Rab-7a/0.526
3kz1GSPTransforming protein RhoA/0.526
4mitGTPRho-related protein racC/0.526
2gcpGSPRho-related GTP-binding protein RhoC/0.525
3l8yGNPGTPase HRas/0.525
4rkfGNPRas-related protein Rab-3/0.525
2fe4GDPRas-related protein Rab-6B/0.524
4o25GTPGTP-binding protein Rheb/0.524
3tnfGNPRas-related protein Rab-8A/0.523
1k5dGNPGTP-binding nuclear protein Ran/0.521
5b2zGNPGTPase HRas/0.521
1e96GTPRas-related C3 botulinum toxin substrate 1/0.520
2zetGTPRas-related protein Rab-27B/0.520
3oiuGNPGTPase HRas/0.520
2ffqGSPRas-related protein Rab-6B/0.519
3lawGNPRas-related protein Rab-7a/0.518
3rs7GNPGTPase HRas/0.518
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.517
3kucGDPRas-related protein Rap-1A/0.512
1vg8GNPRas-related protein Rab-7a/0.511
3a6pGTPGTP-binding nuclear protein Ran/0.511
3ddcGNPGTPase HRas/0.511
1ibrGNPGTP-binding nuclear protein Ran/0.510
3v4fGNPGTPase HRas/0.510
1xtrGNPGTP-binding protein Rheb/0.509
4kvgGTPRas-related protein Rap-1A/0.509
3oivGNPGTPase HRas/0.508
4uj3GNPRas-related protein Rab-11A/0.508
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.506
4dsoGSPGTPase KRas/0.506
3kudGDPGTPase HRas/0.503
3tsoGNPRas-related protein Rab-25/0.502
4g0nGNPGTPase HRas/0.501
4uj5GNPRas-related protein Rab-11A/0.501
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.500
1z2cGNPRho-related GTP-binding protein RhoC/0.499
3rs5GNPGTPase HRas/0.499
1a2bGSPTransforming protein RhoA/0.497
4ol0GTPGTP-binding nuclear protein Ran/0.495
2bkuGTPGTP-binding nuclear protein Ran/0.493
1ow3GDPTransforming protein RhoA/0.492
1yhnGTPRas-related protein Rab-7a/0.492
3tklGTPRas-related protein Rab-1A/0.492
3qbtGNPRas-related protein Rab-8A/0.487
4dsnGCPGTPase KRas/0.487
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.486
4dlwGNPGTPase HRas/0.486
5difGNPGTP-binding nuclear protein Ran/0.484
2rgeGNPGTPase HRas/0.482
3th5GNPRas-related C3 botulinum toxin substrate 1/0.482
1zd9GDPADP-ribosylation factor-like protein 8A/0.481
4dsuGDPGTPase KRas/0.481
2c5lGTPGTPase HRas/0.480
4l9wGNPGTPase HRas/0.480
4dlzGNPGTPase HRas/0.479
5hpyGDPTransforming protein RhoA/0.477
3rs4GNPGTPase HRas/0.476
1z0aGDPRas-related protein Rab-2A/0.473
1oixGDPRas-related protein Rab-11A/0.472
3pitGNPRas-related protein M-Ras/0.472
1m7bGTPRho-related GTP-binding protein RhoE/0.471
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.471
2rgbGNPGTPase HRas/0.471
3oiwGNPGTPase HRas/0.470
3rslGNPGTPase HRas/0.470
3kkoGNPRas-related protein M-Ras/0.468
4dlsGNPGTPase HRas/0.468
4hdoGNPRas-related protein Rap-1b/0.468
4js0GNPCell division control protein 42 homolog/0.466
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.465
4cymGCPRas-related protein Rab-32/0.465
3eg5GNPCell division control protein 42 homolog/0.463
1lfdGNPGTPase HRas/0.462
3cphGDPRas-related protein SEC4/0.462
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.460
3lbiGNPGTPase HRas/0.460
3rs0GNPGTPase HRas/0.460
4tq9GDPGTPase KRas/0.460
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.459
4l9sGDPGTPase HRas/0.457
2cl6CAGGTPase HRas/0.456
2clsGTPRho-related GTP-binding protein Rho6/0.456
4xvrGNPGTPase HRas/0.455
3x1zGNPRas-related protein Rap-1b/0.452
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.452
3lbhGNPGTPase HRas/0.451
4dxaGSPRas-related protein Rap-1b/0.451
2gvdGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.449
4lv6GDPGTPase KRas/0.449
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.448
3tgpGNPGTPase HRas/0.447
4hdqGNPRas-related protein Rap-1b/0.447
1d5cGDPGTPase (Rab6)/0.445
4dlxGNPGTPase HRas/0.445
1uadGNPRas-related protein Ral-A/0.444
2rgcGNPGTPase HRas/0.444
4dlvGNPGTPase HRas/0.444
4b2gV1NUncharacterized protein/0.443
4lrwGDPGTPase KRas/0.443
1s1cGNPTransforming protein RhoA/0.442