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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.62

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.621.000
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.498
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.491
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.487
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.485
1fm4DXCMajor pollen allergen Bet v 1-L/0.471
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.470
4a81DXCMajor pollen allergen Bet v 1-A/0.466
3is9AC7Gag-Pol polyprotein2.7.7.490.465
2po7CHDFerrochelatase, mitochondrial4.99.1.10.459
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.452
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.452
4a83DXCMajor pollen allergen Bet v 1-A/0.447
4a84DXCMajor pollen allergen Bet v 1-A/0.447
1w06W05Isopenicillin N synthase1.21.3.10.443
1osvCHCBile acid receptor/0.442
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1fmjRTLRetinol dehydratase/0.441
3zoiM2WIsopenicillin N synthase1.21.3.10.441
1fmlRTLRetinol dehydratase/0.440
4qe6JN3Bile acid receptor/0.440