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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.62

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.621.000
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.536
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.509
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.497
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.497
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.487
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.484
4bb3KKAIsopenicillin N synthase1.21.3.10.475
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.468
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.461
3cd57HI3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.458
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.456
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.456
2c3qGTXGlutathione S-transferase theta-12.5.1.180.449
3fhxPXLPyridoxal kinase2.7.1.350.449
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.448
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
4jl6ADPAdenylate kinase/0.441
1qiqACCIsopenicillin N synthase1.21.3.10.440