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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1eqgIBPProstaglandin G/H synthase 11.14.99.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1eqgIBPProstaglandin G/H synthase 11.14.99.11.000
1eqhFLPProstaglandin G/H synthase 11.14.99.10.820
4fm5DF0Prostaglandin G/H synthase 21.14.99.10.670
1q4gBFLProstaglandin G/H synthase 11.14.99.10.645
3n8wFLPProstaglandin G/H synthase 11.14.99.10.639
1ht834CProstaglandin G/H synthase 11.14.99.10.635
3pghFLPProstaglandin G/H synthase 21.14.99.10.633
3ntgD72Prostaglandin G/H synthase 21.14.99.10.630
2aylFLPProstaglandin G/H synthase 11.14.99.10.626
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.597
3n8zFLPProstaglandin G/H synthase 11.14.99.10.592
3ln1CELProstaglandin G/H synthase 21.14.99.10.581
4coxIMNProstaglandin G/H synthase 21.14.99.10.581
3n8xNIMProstaglandin G/H synthase 11.14.99.10.577
3q7dNPXProstaglandin G/H synthase 21.14.99.10.570
3rr3FLRProstaglandin G/H synthase 21.14.99.10.568
4ph9IBPProstaglandin G/H synthase 21.14.99.10.563
6coxS58Prostaglandin G/H synthase 21.14.99.10.560
2oyuIMSProstaglandin G/H synthase 11.14.99.10.556
4rrxLURProstaglandin G/H synthase 21.14.99.10.530
5ikrID8Prostaglandin G/H synthase 21.14.99.10.523
3mqe416Prostaglandin G/H synthase 21.14.99.10.522
4rrwLURProstaglandin G/H synthase 21.14.99.10.521
4rrzLURProstaglandin G/H synthase 21.14.99.10.521
3kk6CELProstaglandin G/H synthase 11.14.99.10.514
3ln052BProstaglandin G/H synthase 21.14.99.10.514
4otyLURProstaglandin G/H synthase 21.14.99.10.502
3n8yDIFProstaglandin G/H synthase 11.14.99.10.482
4m10ICDProstaglandin G/H synthase 21.14.99.10.471
3vf60H6Glucokinase2.7.1.20.469
1ht5FL2Prostaglandin G/H synthase 11.14.99.10.465
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.464
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.461
5ikqJMSProstaglandin G/H synthase 21.14.99.10.460
1cbrREACellular retinoic acid-binding protein 1/0.455
1iyzNDPProbable quinone oxidoreductase/0.454
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
1pxxDIFProstaglandin G/H synthase 21.14.99.10.450
4jqh1MFAlr2278 protein/0.450
1vj3TABDihydrofolate reductase1.5.1.30.449
3hk1B64Fatty acid-binding protein, adipocyte/0.448
1disBDMDihydrofolate reductase1.5.1.30.447
2zbzVDXVitamin D3 dihydroxylase/0.447
4a2aATPCell division protein FtsA/0.447
3cd2MTXDihydrofolate reductase1.5.1.30.446
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
1hk3T44Serum albumin/0.445
3gc8B45Mitogen-activated protein kinase 112.7.11.240.445
3nwq2NCGag-Pol polyprotein3.4.23.160.444
3pqbVGPPutative oxidoreductase/0.444
2zevB71Geranylgeranyl pyrophosphate synthase/0.443
3vt7VDXVitamin D3 receptor/0.443
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.443
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.442
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.442
3zkyWT4Isopenicillin N synthase1.21.3.10.442
4dpwAGSMevalonate diphosphate decarboxylase/0.442
1i58ACPChemotaxis protein CheA2.7.13.30.441
2dbrNAPGlyoxylate reductase1.1.1.260.441
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3keuATPPyridoxal kinase2.7.1.350.441
1cx2S58Prostaglandin G/H synthase 21.14.99.10.440
2fziDH3Dihydrofolate reductase1.5.1.30.440
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4ddrMMVDihydrofolate reductase1.5.1.30.440
4qe6JN3Bile acid receptor/0.440
5k2bZMAAdenosine receptor A2a/0.440