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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1eiiRTLRetinol-binding protein 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1eiiRTLRetinol-binding protein 2/1.000
1oc1ASVIsopenicillin N synthase1.21.3.10.470
4y8wSTRSteroid 21-hydroxylase/0.468
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.467
2po7CHDFerrochelatase, mitochondrial4.99.1.10.464
4ipw1G7Mycocyclosin synthase1.14.21.90.464
3h3r14HCollagen type IV alpha-3-binding protein/0.461
2vbdV10Isopenicillin N synthase1.21.3.10.459
3ixp834Ecdysone receptor/0.457
2w3bNDPDihydrofolate reductase1.5.1.30.456
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
3l6jZ90Alr2278 protein/0.456
1tj0FADBifunctional protein PutA1.5.5.20.455
2jb4A14Isopenicillin N synthase1.21.3.10.455
4b4vL34Bifunctional protein FolD/0.455
1me6IVSPlasmepsin-23.4.23.390.453
3lqsPSZD-alanine aminotransferase2.6.1.210.453
3nxxNDPDihydrofolate reductase1.5.1.30.453
2bu9HFVIsopenicillin N synthase1.21.3.10.451
3zcnATPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.451
2bxoOPBSerum albumin/0.450
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.450
1xddAAYIntegrin alpha-L/0.449
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.449
4umxNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.449
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.448
4b4w9L9Bifunctional protein FolD/0.448
4g7gVFVLanosterol 14-alpha-demethylase/0.448
1adfTADAlcohol dehydrogenase E chain1.1.1.10.447
1juvNDPDihydrofolate reductase1.5.1.30.447
3gncQQQGlutaryl-CoA dehydrogenase/0.447
4dc0NDPPutative ketoacyl reductase1.3.10.446
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.445
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.445
4f6w0SSCyclin-dependent kinase 82.7.11.220.445
1geeNADGlucose 1-dehydrogenase1.1.1.470.444
2bl4NADLactaldehyde reductase1.1.1.770.444
2gmhFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.444
4a81DXCMajor pollen allergen Bet v 1-A/0.444
4iah1DXAlr2278 protein/0.444
1ygkRRCPyridoxal kinase2.7.1.350.443
3bg7FADPyranose 2-oxidase/0.443
4b65FADL-ornithine N(5)-monooxygenase/0.443
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.443
2fznFADBifunctional protein PutA1.5.5.20.442
3ekuCY9Actin-5C/0.442
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.442
4g3jVNTLanosterol 14-alpha-demethylase/0.442
3in6FMNUncharacterized protein/0.441
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.441
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.441
4du82P0Mevalonate diphosphate decarboxylase/0.441
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4iae1DXAlr2278 protein/0.441
5idwNAPShort-chain dehydrogenase/reductase SDR/0.440
6stdMS2Scytalone dehydratase4.2.1.940.440