scPDB - Distribution of Binding site Similarity values of 1df7 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1df7	MTX	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1df7	MTX	Dihydrofolate reductase	1.5.1.3	1.000
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.564
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.500
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.491
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.490
2w3v	TOP	Dihydrofolate reductase	/	0.487
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.486
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.486
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.480
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.476
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.475
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.468
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.468
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.466
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.464
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.463
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.461
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.460
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.460
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.459
3eek	53S	Uncharacterized protein	/	0.456
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.455
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.451
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.449
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.448
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.446
3qlz	QLZ	Uncharacterized protein	/	0.446
3cse	N22	Uncharacterized protein	/	0.445
3ia4	MTX	Dihydrofolate reductase	/	0.445
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.443
3tq9	MTX	Dihydrofolate reductase	/	0.443
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.442
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.442
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.442
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.440