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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ad5ANPTyrosine-protein kinase HCK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ad5ANPTyrosine-protein kinase HCK2.7.10.21.000
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.470
4qmlANPSerine/threonine-protein kinase 242.7.11.10.467
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.464
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.461
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.459
4qnyANPMitogen activated protein kinase, putative/0.450
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
5cnoANPEpidermal growth factor receptor2.7.10.10.443