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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.62

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.621.000
1fduESTEstradiol 17-beta-dehydrogenase 11.1.1.620.553
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.536
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.535
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.529
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.514
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.504
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.479
3deyDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.475
3klmDHTEstradiol 17-beta-dehydrogenase 11.1.1.620.475
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.469
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.461
4m4922YL-lactate dehydrogenase A chain1.1.1.270.454
2ok7FADFerredoxin--NADP reductase, apicoplast/0.452
1bk0ACVIsopenicillin N synthase1.21.3.10.450
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.450
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.448
3zkyWT4Isopenicillin N synthase1.21.3.10.447
2jb4A14Isopenicillin N synthase1.21.3.10.444
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.444
4ryvZEAProtein LlR18A/0.443
1s7gNADNAD-dependent protein deacylase 2/0.442
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.442
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3qly55VUncharacterized protein/0.442
3p3zP3ZPutative cytochrome P450/0.441
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2iviACWIsopenicillin N synthase1.21.3.10.440