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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5iqi GNP Bifunctional AAC/APH 2.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5iqi GNPBifunctional AAC/APH 2.3.1 1.055
5iqe GNPBifunctional AAC/APH 2.3.1 0.981
5iqa GNPBifunctional AAC/APH 2.3.1 0.968
5iqd GNPBifunctional AAC/APH 2.3.1 0.909
5iqh GNPBifunctional AAC/APH 2.3.1 0.898
5byl GCPBifunctional AAC/APH 2.3.1 0.888
5iqb GNPBifunctional AAC/APH 2.3.1 0.884
5iqg GDPBifunctional AAC/APH 2.3.1 0.837
4ork GDPBifunctional AAC/APH 2.3.1 0.802
3tdw GDPGentamicin resistance protein / 0.796
5iqf GDPBifunctional AAC/APH 2.3.1 0.776
3tdv GDPGentamicin resistance protein / 0.770
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.719
3ufx GDPSuccinate--CoA ligase [GDP-forming] subunit beta / 0.712
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.711
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.708
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.706
3bu5 ATPInsulin receptor 2.7.10.1 0.705
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.705
4utd ACPAurora kinase A 2.7.11.1 0.704
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.700
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.699
4xlv ACPInsulin receptor 2.7.10.1 0.694
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.692
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.688
1mq4 ADPAurora kinase A 2.7.11.1 0.688
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.686
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4ceg ADPAurora kinase A 2.7.11.1 0.685
3dyn PCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A / 0.684
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
5dn3 ATPAurora kinase A 2.7.11.1 0.684
3pff ADPATP-citrate synthase 2.3.3.8 0.683
2pui ADPMethylthioribose kinase 2.7.1.100 0.682
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.682
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.681
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.680
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.679
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.679
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.678
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.678
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.678
5ce3 ADPProtein kinase YopO / 0.678
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.677
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.677
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.676
2pyw ADPMethylthioribose kinase 2.7.1.100 0.676
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.675
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.675
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.675
4dee ADPAurora kinase A 2.7.11.1 0.675
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.672
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
5dt3 ATPAurora kinase A 2.7.11.1 0.672
5drd ATPAurora kinase A 2.7.11.1 0.669
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.668
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.667
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.667
4gyi ADPUncharacterized protein / 0.667
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.667
4n57 ADPAPH(2'')-Id / 0.666
1m0w ANPGlutathione synthetase 6.3.2.3 0.665
3c50 ADPRhodopsin kinase / 0.665
3rv4 ADPBiotin carboxylase 6.3.4.14 0.665
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.665
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.664
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.664
4ffm ADPUncharacterized protein / 0.663
5dos ATPAurora kinase A 2.7.11.1 0.663
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.662
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.661
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.661
2olc ADPMethylthioribose kinase 2.7.1.100 0.658
2zxu DSTtRNA dimethylallyltransferase 2.5.1.75 0.658
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.658
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.657
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
5dnr ATPAurora kinase A 2.7.11.1 0.656
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.655
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.655
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.655
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.655
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.654
4qbg AP5Adenylate kinase / 0.652
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.651
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.650
1tu3 GNPRas-related protein Rab-5A / 0.650
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.650