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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ios FAD Flavin-dependent thymidylate synthase 2.1.1.148

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5ios FADFlavin-dependent thymidylate synthase 2.1.1.148 1.388
3g4a FADFlavin-dependent thymidylate synthase 2.1.1.148 1.293
3n0c FADFlavin-dependent thymidylate synthase 2.1.1.148 1.290
1o29 FADFlavin-dependent thymidylate synthase 2.1.1.148 1.201
3n0b FADFlavin-dependent thymidylate synthase 2.1.1.148 1.181
1kq4 FADFlavin-dependent thymidylate synthase 2.1.1.148 1.052
4gte FADFlavin-dependent thymidylate synthase 2.1.1.148 1.037
4p5a FADFlavin-dependent thymidylate synthase / 1.010
4gtl FADFlavin-dependent thymidylate synthase 2.1.1.148 0.985
3ah5 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.922
2af6 FADFlavin-dependent thymidylate synthase 2.1.1.148 0.905
4p5b FADFlavin-dependent thymidylate synthase / 0.874
4kar FADFlavin-dependent thymidylate synthase 2.1.1.148 0.863
3gwc FADFlavin-dependent thymidylate synthase 2.1.1.148 0.861
3hzg FADFlavin-dependent thymidylate synthase 2.1.1.148 0.699
2aky AP5Adenylate kinase / 0.678
3enk UPGUDP-glucose 4-epimerase / 0.664
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.659
1udb UFGUDP-glucose 4-epimerase 5.1.3.2 0.658
1udc UFMUDP-glucose 4-epimerase 5.1.3.2 0.656
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.654
2gn4 UD1UDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.652
2fcr FMNFlavodoxin / 0.651