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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hid B1E Serine/threonine-protein kinase B-raf 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 1.230
4fc0 0T2Serine/threonine-protein kinase B-raf 2.7.11.1 0.906
4aa0 AA0Mitogen-activated protein kinase 14 / 0.795
3d83 GK6Mitogen-activated protein kinase 14 / 0.781
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.776
2bak AQZMitogen-activated protein kinase 14 / 0.774
4a9y AQZMitogen-activated protein kinase 14 / 0.774
3bv2 P38Mitogen-activated protein kinase 14 / 0.771
3bv3 P39Mitogen-activated protein kinase 14 / 0.761
1w83 L11Mitogen-activated protein kinase 14 / 0.756
3uvr 06FMitogen-activated protein kinase 14 / 0.752
4ksp 1SUSerine/threonine-protein kinase B-raf 2.7.11.1 0.746
1wbt WBTMitogen-activated protein kinase 14 / 0.745
4r7i STIMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.737
1wbs LI2Mitogen-activated protein kinase 14 / 0.735
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.733
2osc MUHAngiopoietin-1 receptor 2.7.10.1 0.721
3hv4 L51Mitogen-activated protein kinase 14 / 0.716
3hv5 R24Mitogen-activated protein kinase 14 / 0.716
3uvq FS8Mitogen-activated protein kinase 14 / 0.703
2oiq STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.692
1wbv LI3Mitogen-activated protein kinase 14 / 0.691
3e93 19BMitogen-activated protein kinase 14 / 0.690
4i5h G17Mitogen-activated protein kinase 1 2.7.11.24 0.685
3gcu R48Mitogen-activated protein kinase 14 / 0.684
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.681
3o8u BMUMitogen-activated protein kinase 14 / 0.675
3e92 G6AMitogen-activated protein kinase 14 / 0.669
3oc1 BMUMitogen-activated protein kinase 14 / 0.669
3gcv SS6Mitogen-activated protein kinase 14 / 0.667
3s4q NK0Mitogen-activated protein kinase 14 / 0.667
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.666
3bx5 304Mitogen-activated protein kinase 14 / 0.665
2puc GUNHTH-type transcriptional repressor PurR / 0.664
3itz P66Mitogen-activated protein kinase 14 / 0.663
3uvp 048Mitogen-activated protein kinase 14 / 0.660
3nnw EDDMitogen-activated protein kinase 14 / 0.659
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 0.657
3o8t BMUMitogen-activated protein kinase 14 / 0.654
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.653
3wff WFFMineralocorticoid receptor / 0.653
4ag8 AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.653
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.652
3vnt 0JAVascular endothelial growth factor receptor 2 2.7.10.1 0.652
4kin 1M8Mitogen-activated protein kinase 14 / 0.652
3o8p BMUMitogen-activated protein kinase 14 / 0.650