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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5f59 SAH Histone-lysine N-methyltransferase 2C 2.1.1.43

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5f59 SAHHistone-lysine N-methyltransferase 2C 2.1.1.43 0.943
4z4p SAHHistone-lysine N-methyltransferase 2D 2.1.1.43 0.822
5jhn SAMHistone-lysine N-methyltransferase EHMT2 / 0.795
2o8j SAHHistone-lysine N-methyltransferase EHMT2 / 0.783
3hna SAHHistone-lysine N-methyltransferase EHMT1 / 0.776
4qen SAHHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 2.1.1.43 0.776
3ooi SAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 2.1.1.43 0.772
3kmt SAHHistone H3K27 methylase / 0.770
5jj0 SAMHistone-lysine N-methyltransferase EHMT2 / 0.765
4h12 SAHHistone-lysine N-methyltransferase SETD2 2.1.1.43 0.760
2rfi SAHHistone-lysine N-methyltransferase EHMT1 / 0.753
5jin SAMHistone-lysine N-methyltransferase EHMT2 / 0.749
4ypu SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.748
3swc SAHHistone-lysine N-methyltransferase EHMT1 / 0.747
4ypa SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.747
3fpd SAHHistone-lysine N-methyltransferase EHMT1 / 0.743
4au7 SAHHistone-lysine N-methyltransferase KMT5C 2.1.1.43 0.719
4ynm SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.717
3qwp SAMHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.711
4ynp SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.711
1ozv SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.703
3m53 SAHHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.698
2igq SAHHistone-lysine N-methyltransferase EHMT1 / 0.696
5czy SAMEukaryotic huntingtin interacting protein B / 0.696
4j83 SAMHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.690
2h23 SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.689
1mlv SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.688
1n6c SAMHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.688
3cbp SFGHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.685
4ype SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.681
3pdn SFGHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.679
2h21 SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.678
4o30 SAHProbable Histone-lysine N-methyltransferase ATXR5 2.1.1.43 0.678
3mo0 SAHHistone-lysine N-methyltransferase EHMT1 / 0.673
5hyn SAHHistone-lysine N-methyltransferase EZH2 2.1.1.43 0.673
3oxf SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.664
3s8p SAMHistone-lysine N-methyltransferase KMT5B 2.1.1.43 0.659
5hq8 SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.659
2r3a SAMHistone-lysine N-methyltransferase SUV39H2 2.1.1.43 0.656
4bup SAMHistone-lysine N-methyltransferase KMT5B 2.1.1.43 0.656
2bqz SAHN-lysine methyltransferase KMT5A / 0.652
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.650