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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5cc9 DDF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5cc9 DDFDihydrofolate reductase 1.5.1.3 1.047
5ccc DDFDihydrofolate reductase 1.5.1.3 0.868
1dyj DDFDihydrofolate reductase 1.5.1.3 0.858
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.796
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.796
4p66 MTXDihydrofolate reductase / 0.790
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.768
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.766
2drc MTXDihydrofolate reductase 1.5.1.3 0.755
1jol FFODihydrofolate reductase 1.5.1.3 0.754
3drc MTXDihydrofolate reductase 1.5.1.3 0.754
5hi6 MTXDihydrofolate reductase / 0.753
1df7 MTXDihydrofolate reductase 1.5.1.3 0.750
4kjj FOLDihydrofolate reductase 1.5.1.3 0.750
4i1n FOLDihydrofolate reductase 1.5.1.3 0.749
1drb MTXDihydrofolate reductase 1.5.1.3 0.744
4i13 FOLDihydrofolate reductase 1.5.1.3 0.743
3och 2MXDihydrofolate reductase 1.5.1.3 0.742
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.740
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.739
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.739
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.739
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.738
1jom FFODihydrofolate reductase 1.5.1.3 0.732
1dhi MTXDihydrofolate reductase 1.5.1.3 0.729
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.729
1dyi FOLDihydrofolate reductase 1.5.1.3 0.726
4x5h FOLDihydrofolate reductase 1.5.1.3 0.726
4kfj FOLDihydrofolate reductase 1.5.1.3 0.724
1dra MTXDihydrofolate reductase 1.5.1.3 0.714
4qi9 MTXDihydrofolate reductase / 0.712
1ohj COPDihydrofolate reductase 1.5.1.3 0.711
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.711
7dfr FOLDihydrofolate reductase 1.5.1.3 0.711
1hfr MOTDihydrofolate reductase 1.5.1.3 0.710
3dau MTXDihydrofolate reductase 1.5.1.3 0.709
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.707
1dhj MTXDihydrofolate reductase 1.5.1.3 0.706
4dfr MTXDihydrofolate reductase 1.5.1.3 0.706
4m6k FOLDihydrofolate reductase 1.5.1.3 0.705
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.701
1re7 FOLDihydrofolate reductase 1.5.1.3 0.701
4x5g FOLDihydrofolate reductase 1.5.1.3 0.701
3frd DHFDihydrofolate reductase 1.5.1.3 0.698
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.696
4p68 MTXDihydrofolate reductase / 0.696
1hfq MOTDihydrofolate reductase 1.5.1.3 0.694
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.694
3dfr MTXDihydrofolate reductase 1.5.1.3 0.689
3tqb FOLDihydrofolate reductase / 0.688
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.686
3tq9 MTXDihydrofolate reductase / 0.684
1tdr MTXDihydrofolate reductase 1.5.1.3 0.681
1ddr MTXDihydrofolate reductase 1.5.1.3 0.680
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.680
4x5f FOLDihydrofolate reductase 1.5.1.3 0.680
1hfp MOTDihydrofolate reductase 1.5.1.3 0.679
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.677
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.673
1wop FFOAminomethyltransferase / 0.673
1dyh DZFDihydrofolate reductase 1.5.1.3 0.672
2d0k FOLDihydrofolate reductase 1.5.1.3 0.672
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.671
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.670
1hbn TP7Methyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.669
1hbn TP7Methyl-coenzyme M reductase I subunit beta 2.8.4.1 0.669
1woo THGAminomethyltransferase / 0.669
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.667
1w06 W05Isopenicillin N synthase 1.21.3.1 0.666
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.666
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.664
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.664
1dls MTXDihydrofolate reductase 1.5.1.3 0.663
2w3m FOLDihydrofolate reductase 1.5.1.3 0.663
1ohk COPDihydrofolate reductase 1.5.1.3 0.661
1obn ASVIsopenicillin N synthase 1.21.3.1 0.657
3ghw GHWDihydrofolate reductase 1.5.1.3 0.657
4m6l 21VDihydrofolate reductase 1.5.1.3 0.657
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.654
4keb FOLDihydrofolate reductase 1.5.1.3 0.654
1drf FOLDihydrofolate reductase 1.5.1.3 0.653
3ar4 ATPSarcoplasmic/endoplasmic reticulum calcium ATPase 1 3.6.3.8 0.653
3mvw BHZNickel-binding periplasmic protein / 0.653
3lnc 5GPGuanylate kinase / 0.652
1dds MTXDihydrofolate reductase 1.5.1.3 0.651
1lvg 5GPGuanylate kinase 2.7.4.8 0.651
4x5i FOLDihydrofolate reductase 1.5.1.3 0.651
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.650
1u70 MTXDihydrofolate reductase 1.5.1.3 0.650
2zza FOLDihydrofolate reductase / 0.650