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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5c4i TPP Oxalate oxidoreductase subunit alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5c4i TPPOxalate oxidoreductase subunit alpha / 1.215
5c4i TPPOxalate oxidoreductase subunit beta / 1.215
5exd TPPOxalate oxidoreductase subunit alpha / 1.041
5exd TPPOxalate oxidoreductase subunit beta / 1.041
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.845
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.844
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.843
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 0.815
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.812
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.809
5ahk TPPAcetolactate synthase II, large subunit / 0.801
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.798
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.796
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.796
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.794
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.793
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.793
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.791
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.787
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.785
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.779
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.777
4cok TPPPyruvate decarboxylase / 0.771
3iae D7KBenzaldehyde lyase / 0.763
2c3y HTLPyruvate synthase / 0.761
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.759
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.759
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.758
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.757
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.756
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.756
1pox TPPPyruvate oxidase 1.2.3.3 0.751
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.746
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.744
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.743
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.743
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.742
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.740
2uza HTLPyruvate synthase / 0.737
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.736
1y9d TPPPyruvate oxidase 1.2.3.3 0.734
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.734
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.733
2pan TDPGlyoxylate carboligase 4.1.1.47 0.731
2uz1 TPPBenzaldehyde lyase / 0.729
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.728
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.728
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.727
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.727
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.725
1kek HTLPyruvate synthase / 0.724
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.723
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.717
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.717
2ag0 TPPBenzaldehyde lyase / 0.715
2c3p 1TPPyruvate synthase / 0.714
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.714
2ezt TDMPyruvate oxidase 1.2.3.3 0.712
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.712
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.710
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.710
3d7k D7KBenzaldehyde lyase / 0.709
4qpz TPPBenzaldehyde lyase / 0.708
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.707
3iaf TPPBenzaldehyde lyase / 0.705
3zhu TD8Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.704
1pow TPPPyruvate oxidase 1.2.3.3 0.702
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.701
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.701
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.699
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.699
2pda TPPPyruvate synthase / 0.697
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.694
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.693
2ez9 TDKPyruvate oxidase 1.2.3.3 0.692
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.691
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.690
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.690
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 0.689
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.687
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.686
3zhv TDWMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.686
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 0.685
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 0.685
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.684
1ozh HE3Acetolactate synthase, catabolic 2.2.1.6 0.682
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.681
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.680
2iea TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.679
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.676
3zht TD9Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.675
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.673
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.673
2c3u 2TPPyruvate synthase / 0.672
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.672
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.669
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.668
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.665
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.661
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.661
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.658
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.658
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.655
4yj2 GTPTubulin alpha-1B chain / 0.655
2c3o TPPPyruvate synthase / 0.654
4tuy GTPTubulin alpha-1B chain / 0.653
2c42 TPPPyruvate synthase / 0.651