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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ar4 SB2 Receptor-interacting serine/threonine-protein kinase 2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5ar4 SB2Receptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.986
3mpa SB2Mitogen-activated protein kinase 14 / 0.679
4kb8 1QNCasein kinase I isoform delta 2.7.11.1 0.673
3vry B43Tyrosine-protein kinase HCK 2.7.10.2 0.670
3vs4 VSFTyrosine-protein kinase HCK 2.7.10.2 0.669
3uib SB2Putative mitogen-activated protein kinase / 0.666
3uzp 0CKCasein kinase I isoform delta 2.7.11.1 0.664
3vs3 VSETyrosine-protein kinase HCK 2.7.10.2 0.664
3hl7 I47Mitogen-activated protein kinase 14 / 0.654
4d9t 0JGRibosomal protein S6 kinase alpha-3 2.7.11.1 0.652
4kbc 1QJCasein kinase I isoform delta 2.7.11.1 0.650