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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4yu1 53N Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4yu1 53NAldose reductase 1.1.1.21 0.903
2ikj 393Aldose reductase 1.1.1.21 0.776
2pdc 393Aldose reductase 1.1.1.21 0.766
2pzn 393Aldose reductase 1.1.1.21 0.763
3m64 393Aldose reductase 1.1.1.21 0.763
2pdp 393Aldose reductase 1.1.1.21 0.743
3mc5 393Aldose reductase 1.1.1.21 0.735
3t42 3T4Aldose reductase 1.1.1.21 0.726
2pdj 393Aldose reductase 1.1.1.21 0.715
2pdm ZSTAldose reductase 1.1.1.21 0.707
2hvo ZSTAldose reductase 1.1.1.21 0.702
2dux ZSTAldose reductase 1.1.1.21 0.695
3m4h 388Aldose reductase 1.1.1.21 0.690
2pdh 47DAldose reductase 1.1.1.21 0.689
3mb9 ZSTAldose reductase 1.1.1.21 0.680
2iki 388Aldose reductase 1.1.1.21 0.679
3ghr LDTAldose reductase 1.1.1.21 0.675
3ghs LDTAldose reductase 1.1.1.21 0.675
2ikh LITAldose reductase 1.1.1.21 0.674
2qxw LDTAldose reductase 1.1.1.21 0.672
1z89 62PAldose reductase 1.1.1.21 0.667
3lbo LDTAldose reductase 1.1.1.21 0.665
3lz5 LDTAldose reductase 1.1.1.21 0.664
2pdn 47DAldose reductase 1.1.1.21 0.660
2pdf ZSTAldose reductase 1.1.1.21 0.659
2pdu 393Aldose reductase 1.1.1.21 0.658
3ght LDTAldose reductase 1.1.1.21 0.658
3lql LDTAldose reductase 1.1.1.21 0.658
2i17 LDTAldose reductase 1.1.1.21 0.653
2pdg 47DAldose reductase 1.1.1.21 0.653
1us0 LDTAldose reductase 1.1.1.21 0.652
2i16 LDTAldose reductase 1.1.1.21 0.652