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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ypa SAM Histone-lysine N-methyltransferase ASH1L 2.1.1.43

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ypa SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 1.099
4ynm SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 1.031
4h12 SAHHistone-lysine N-methyltransferase SETD2 2.1.1.43 0.993
5jhn SAMHistone-lysine N-methyltransferase EHMT2 / 0.922
3ooi SAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 2.1.1.43 0.920
5jin SAMHistone-lysine N-methyltransferase EHMT2 / 0.890
5jj0 SAMHistone-lysine N-methyltransferase EHMT2 / 0.890
4ynp SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.865
2r3a SAMHistone-lysine N-methyltransferase SUV39H2 2.1.1.43 0.833
3tg4 SAMN-lysine methyltransferase SMYD2 / 0.833
4ype SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.822
4ypu SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.815
2o8j SAHHistone-lysine N-methyltransferase EHMT2 / 0.808
2h21 SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.792
1n6c SAMHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.787
4o30 SAHProbable Histone-lysine N-methyltransferase ATXR5 2.1.1.43 0.771
4z4p SAHHistone-lysine N-methyltransferase 2D 2.1.1.43 0.770
3hna SAHHistone-lysine N-methyltransferase EHMT1 / 0.766
3m53 SAHHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.759
5czy SAMEukaryotic huntingtin interacting protein B / 0.756
5f59 SAHHistone-lysine N-methyltransferase 2C 2.1.1.43 0.747
3oxf SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.740
4o6f SAHN-lysine methyltransferase SMYD2 / 0.738
2bqz SAHN-lysine methyltransferase KMT5A / 0.730
2h23 SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.730
5ex0 SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.719
3rib SAHN-lysine methyltransferase SMYD2 / 0.667
2dv7 SAHDiphthine synthase / 0.665
2emu SAHDiphthine synthase / 0.664
2pb5 SAHDiphthine synthase / 0.664
2p6d SAHDiphthine synthase / 0.663
2dv3 SAHDiphthine synthase / 0.662
2eh5 SAHDiphthine synthase / 0.662
2ek4 SAHDiphthine synthase / 0.662
2pck SAHDiphthine synthase / 0.662
2dsh SAHDiphthine synthase / 0.661
1p0y SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.660
2dsi SAHDiphthine synthase / 0.660
2egs SAHDiphthine synthase / 0.658
2pcm SAHDiphthine synthase / 0.657
3ndc SAHPrecorrin-4 C(11)-methyltransferase 2.1.1.133 0.656
1ozv SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.653
2egv SAMRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.652
4j83 SAMHistone-lysine N-methyltransferase SETD7 2.1.1.43 0.652
2ejj SAHDiphthine synthase / 0.650
2ejz SAHDiphthine synthase / 0.650
2igq SAHHistone-lysine N-methyltransferase EHMT1 / 0.650