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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ynp SAM Histone-lysine N-methyltransferase ASH1L 2.1.1.43

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ynp SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 1.049
4ypu SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.870
4ypa SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.865
4ynm SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.861
5jhn SAMHistone-lysine N-methyltransferase EHMT2 / 0.849
3ooi SAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific 2.1.1.43 0.843
5jj0 SAMHistone-lysine N-methyltransferase EHMT2 / 0.839
4h12 SAHHistone-lysine N-methyltransferase SETD2 2.1.1.43 0.836
5jin SAMHistone-lysine N-methyltransferase EHMT2 / 0.817
3swc SAHHistone-lysine N-methyltransferase EHMT1 / 0.806
2r3a SAMHistone-lysine N-methyltransferase SUV39H2 2.1.1.43 0.804
2o8j SAHHistone-lysine N-methyltransferase EHMT2 / 0.784
4ype SAMHistone-lysine N-methyltransferase ASH1L 2.1.1.43 0.767
4qen SAHHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4 2.1.1.43 0.765
4z4p SAHHistone-lysine N-methyltransferase 2D 2.1.1.43 0.743
1p0y SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.735
5czy SAMEukaryotic huntingtin interacting protein B / 0.733
2h21 SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.728
4bup SAMHistone-lysine N-methyltransferase KMT5B 2.1.1.43 0.722
3hna SAHHistone-lysine N-methyltransferase EHMT1 / 0.719
3tg4 SAMN-lysine methyltransferase SMYD2 / 0.716
2bqz SAHN-lysine methyltransferase KMT5A / 0.713
5f59 SAHHistone-lysine N-methyltransferase 2C 2.1.1.43 0.711
3kmt SAHHistone H3K27 methylase / 0.698
3mo0 SAHHistone-lysine N-methyltransferase EHMT1 / 0.693
3s8p SAMHistone-lysine N-methyltransferase KMT5B 2.1.1.43 0.688
4o6f SAHN-lysine methyltransferase SMYD2 / 0.683
4o30 SAHProbable Histone-lysine N-methyltransferase ATXR5 2.1.1.43 0.682
2igq SAHHistone-lysine N-methyltransferase EHMT1 / 0.681
3oxf SAHHistone-lysine N-methyltransferase SMYD3 2.1.1.43 0.672
2h23 SAHRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic 2.1.1.127 0.670
2egv SAMRibosomal RNA small subunit methyltransferase E 2.1.1.193 0.667