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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4w5k PLP Aspartate aminotransferase, mitochondrial

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4w5k PLPAspartate aminotransferase, mitochondrial / 1.022
4ge9 0L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.878
4geb 0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.875
4ge4 0KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.874
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 0.852
4gdy 0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.842
4wlj IK2Kynurenine--oxoglutarate transaminase 1 2.6.1.7 0.838
1oxo IK2Aspartate aminotransferase, mitochondrial 2.6.1.1 0.837
1arg PPDAspartate aminotransferase 2.6.1.1 0.826
1maq PGUAspartate aminotransferase, mitochondrial 2.6.1.1 0.817
1cq8 PY6Aspartate aminotransferase 2.6.1.1 0.812
1u08 PLPMethionine aminotransferase / 0.804
1x28 PGUAspartate aminotransferase 2.6.1.1 0.793
1ahg TYR_PLPAspartate aminotransferase 2.6.1.1 0.753
4ge7 0K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.745
3qpg 3QPAspartate aminotransferase 2.6.1.1 0.734
1cq7 PY5Aspartate aminotransferase 2.6.1.1 0.728
1cq6 PY4Aspartate aminotransferase 2.6.1.1 0.723
3ei8 PL5LL-diaminopimelate aminotransferase, chloroplastic / 0.723
3ele PLPAminotransferase / 0.711
1arh PPDAspartate aminotransferase 2.6.1.1 0.700
4je5 PLPAromatic/aminoadipate aminotransferase 1 2.6.1.39 0.700
4eb5 PLPCysteine desulfurase IscS 2 / 0.695
1b9i PXG3-amino-5-hydroxybenzoate synthase 4.2.1.144 0.689
2ycn P61Tyrosine phenol-lyase 4.1.99.2 0.688
1asc NPLAspartate aminotransferase 2.6.1.1 0.672
4emy PLPAminotransferase class I and II / 0.672
4rkd KETAminotransferase / 0.672
1a4i NDPC-1-tetrahydrofolate synthase, cytoplasmic 1.5.1.5 0.668
3zrr PXGSerine-pyruvate aminotransferase (AgxT) / 0.664
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.659
3aej AA5Methionine gamma-lyase / 0.658
3ojx NAPNADPH--cytochrome P450 reductase / 0.657
4hh4 SAHCcbJ / 0.657
3eo8 FMNPutative nitroreductase / 0.655
1c0a AMOAspartate--tRNA ligase / 0.654
4eb7 PLPCysteine desulfurase IscS 2 / 0.653
2gqn BLPCystathionine beta-lyase MetC 4.4.1.8 0.652