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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4tnp DCP Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4tnp DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.334
4tnq TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.187
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.167
4tnx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.161
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.156
4to6 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.146
4to3 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.135
4tnz DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.124
4qfx DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.069
4qfy DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.056
4zwg DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.000
4to5 TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.967
4tnr DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.966
4tny DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.951
4bzc T8TDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.849
2pz8 APCNH(3)-dependent NAD(+) synthetase / 0.673
1mdu ATPActin, alpha skeletal muscle / 0.672
4lfv YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.671
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.668
4to5 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.668
4tnz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.666
3cx4 ADPGlycogen synthase 2.4.1.21 0.664
1n6l GTPRas-related protein Rab-5A / 0.660
2fah GDPPhosphoenolpyruvate carboxykinase [GTP], mitochondrial 4.1.1.32 0.659
3h5n ATPMccB protein / 0.658
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.655
2gil GTPRas-related protein Rab-6A / 0.654
3e5h GNPRas-related protein Rab-28 / 0.654
1cg4 IMOAdenylosuccinate synthetase / 0.653
3t3f N5PDNA polymerase I, thermostable 2.7.7.7 0.653
4ee3 UDHBeta-1,4-galactosyltransferase 1 / 0.653
4bzb DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.652
1dlj UGAUDP-glucose 6-dehydrogenase / 0.650