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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4rnu FMN NADPH dehydrogenase 1 1.6.99.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 1.027
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.859
4tmc FMNOld yellow enzyme / 0.818
3atz FMNProstaglandin F2a synthase / 0.813
2h8x FMNXenA / 0.806
4tmb FMNOld yellow enzyme / 0.802
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.799
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.796
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.791
4e2d FMNDehydrogenase / 0.789
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.787
3aty FMNProstaglandin F2a synthase / 0.786
1h63 FMNPentaerythritol tetranitrate reductase / 0.781
3n19 FNRXenobiotic reductase / 0.780
4e2b FMNDehydrogenase / 0.780
4jic FMNGTN Reductase / 0.778
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.775
1gwj FMNMorphinone reductase / 0.773
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.772
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.771
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.770
3p8i FMNPentaerythritol tetranitrate reductase / 0.768
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.766
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.766
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.765
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.765
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.762
3p67 FMNPentaerythritol tetranitrate reductase / 0.760
3l67 FMNXenobiotic reductase / 0.759
3p84 FMNPentaerythritol tetranitrate reductase / 0.759
3p8j FMNPentaerythritol tetranitrate reductase / 0.759
1vyr FMNPentaerythritol tetranitrate reductase / 0.756
1vhn FMNtRNA-dihydrouridine synthase / 0.755
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.755
5cpm FNRNADH:flavin oxidoreductase / 0.755
2abb FMNPentaerythritol tetranitrate reductase / 0.752
3gka FMNN-ethylmaleimide reductase / 0.749
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.747
1h50 FMNPentaerythritol tetranitrate reductase / 0.742
1h51 FMNPentaerythritol tetranitrate reductase / 0.742
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.742
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.741
3f03 FMNPentaerythritol tetranitrate reductase / 0.740
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.737
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.735
4utk FNRXenobiotic reductase / 0.734
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.733
3p62 FMNPentaerythritol tetranitrate reductase / 0.731
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.727
1z41 FMNNADPH dehydrogenase / 0.726
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.725
4yco FMNtRNA-dihydrouridine(16) synthase / 0.723
4qai FMNNADPH dehydrogenase / 0.720
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.720
3p74 FMNPentaerythritol tetranitrate reductase / 0.713
3p82 FMNPentaerythritol tetranitrate reductase / 0.712
4utm FNRXenobiotic reductase / 0.712
2j6x FMNLactate oxidase / 0.705
3tjl FMNNADPH dehydrogenase / 0.705
4df2 FMNNADPH dehydrogenase / 0.705
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.704
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.703
3n14 FMNXenobiotic reductase / 0.703
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.701
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.699
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.698
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.688
4cw5 FMNDfnA / 0.687
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.686
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.686
2b3d FADModulator of drug activity B / 0.683
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.682
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.680
1h69 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.679
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.677
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.677
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.672
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.671
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.669
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.669
4m5p FMNNADPH dehydrogenase / 0.668
2vyx FMNDodecin / 0.667
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.666
4r38 RBFBlue-light-activated histidine kinase 2 2.7.13.3 0.664
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.661
2gjl FMNNitronate monooxygenase 1.13.12.16 0.657
2fre FMNNAD(P)H-flavin oxidoreductase / 0.656
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.655
3w77 FMNFMN-dependent NADH-azoreductase / 0.654
3klb FMNUncharacterized protein / 0.652
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.650
4gi5 FADPutative NAD(P)H dehydrogenase (Quinone) / 0.650