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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4r1f ADP DNA topoisomerase 2-alpha 5.99.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4r1f ADPDNA topoisomerase 2-alpha 5.99.1.3 1.027
1zxn ADPDNA topoisomerase 2-alpha 5.99.1.3 0.876
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.802
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.793
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.764
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.717
4ipe ANPTNF receptor-associated protein 1 / 0.716
3a0t ADPSensor histidine kinase / 0.704
4ivg ANPTNF receptor-associated protein 1 / 0.699
3sl2 ATPSensor histidine kinase WalK / 0.693
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.677
4prv ADPDNA gyrase subunit B / 0.669
4r3a ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.664
4prx ADPDNA gyrase subunit B / 0.662
4r39 ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.660
3ehj ACPSensor histidine kinase DesK 2.7.13.3 0.656
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.656
1z5a ADPType 2 DNA topoisomerase 6 subunit B / 0.650