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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4qfx DGT Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4qfx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.265
4bzb DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.230
4qfy DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.162
4to4 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.088
4to3 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.032
4qg1 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.028
4qfz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.020
4to2 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 1.015
4to1 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.981
4to0 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.972
4mz7 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.952
4qg0 DUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.883
4to6 TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.879
4to5 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.871
4rxp DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.869
4tny DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.858
4rxr DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.815
4rxs TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.807
4tnz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.793
4rxq DUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.763
4zwe DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.684
3rye UNRFarnesyl pyrophosphate synthase 2.5.1.10 0.683
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.673
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.673
4db1 ANPMyosin-7 / 0.669
1n75 ATPGlutamate--tRNA ligase 6.1.1.17 0.665
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.662
5bsm ATP4-coumarate--CoA ligase 2 6.2.1.12 0.661
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.659
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.658
3bbp GTPRas-related protein Rab-6A / 0.653
3qi2 GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.652