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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4q23 RIS Farnesyl pyrophosphate synthase 2.5.1.10

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4q23 RISFarnesyl pyrophosphate synthase 2.5.1.10 1.037
4kqs RISFarnesyl pyrophosphate synthase 2.5.1.10 1.024
4nke RISFarnesyl pyrophosphate synthase 2.5.1.10 0.959
4lfv YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.945
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.944
4h5d YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.939
1yv5 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.932
3rye UNRFarnesyl pyrophosphate synthase 2.5.1.10 0.924
4dxj 0M9Farnesyl pyrophosphate synthase / 0.916
3ez3 ZOLFarnesyl pyrophosphate synthase, putative / 0.915
4dem YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.910
4h5c YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.910
3icz PB6Farnesyl pyrophosphate synthase / 0.895
3dyh 721Farnesyl pyrophosphate synthase / 0.889
4ga3 4GAFarnesyl pyrophosphate synthase 2.5.1.10 0.886
4dwb 0M7Farnesyl pyrophosphate synthase / 0.865
3ldw ZOLFarnesyl pyrophosphate synthase, putative / 0.848
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.842
2z52 H23Geranylgeranyl pyrophosphate synthase / 0.812
3egt 722Farnesyl pyrophosphate synthase / 0.797
4l2x YL2Farnesyl pyrophosphate synthase 2.5.1.10 0.794
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.785
2f94 BFQFarnesyl pyrophosphate synthase 2.5.1.10 0.783
3rbm B73Farnesyl pyrophosphate synthase, putative / 0.782
2i19 1BYFarnesyl pyrophosphate synthase / 0.776
1yq7 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.773
3ryw K9HFarnesyl pyrophosphate synthase, putative / 0.765
2z4w 749Geranylgeranyl pyrophosphate synthase / 0.752
2e95 B75Geranylgeranyl pyrophosphate synthase / 0.741
3krf DSTGeranyl diphosphate synthase large subunit / 0.739
2o1o RISPutative farnesyl pyrophosphate synthase / 0.731
5erm 210Fusicoccadiene synthase 4.2.3.43 0.730
2zev B71Geranylgeranyl pyrophosphate synthase / 0.719
2e91 ZOLGeranylgeranyl pyrophosphate synthase / 0.710
2opm NI9Farnesyl pyrophosphate synthase 2.5.1.10 0.707
3dt2 GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.699
3dt4 GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.699
2e8w IPEGeranylgeranyl pyrophosphate synthase / 0.687
2py7 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.683
5ero 210Fusicoccadiene synthase 2.5.1.29 0.682
1khe GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.677
1svm ATPLarge T antigen 3.6.4 0.676
2zcq B65Dehydrosqualene synthase / 0.675
1g4p FQPThiamine-phosphate synthase / 0.671
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.668
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.667
1ytm ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.665
2jiz ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.664
4nu0 AP5Adenylate kinase / 0.664
1x1a SAMC-20 methyltransferase / 0.663
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.663
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.661
4tl6 ANPCircadian clock protein kinase KaiC 2.7.11.1 0.660
3s87 DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.655
5i4n ATPTyrosine-protein kinase JAK2 / 0.655
2cvx DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.653
4tl7 ATPCircadian clock protein kinase KaiC 2.7.11.1 0.653