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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4oth DRN Serine/threonine-protein kinase N1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4oth DRNSerine/threonine-protein kinase N1 / 1.094
4e5i 0N9Polymerase acidic protein / 0.744
1uvr BI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.742
1uu8 BI13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.709
1uu7 BI23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.706
2jed LG8Protein kinase C theta type 2.7.11.13 0.695
2vd5 BI8Myotonin-protein kinase 2.7.11.1 0.693
3orz BI43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.692
1zrz BI1Protein kinase C iota type 2.7.11.13 0.687
2bik BI1Serine/threonine-protein kinase pim-1 2.7.11.1 0.684
1xws BI1Serine/threonine-protein kinase pim-1 2.7.11.1 0.681
2bfy H1NAurora kinase B-A 2.7.11.1 0.672
2ym5 YM5Serine/threonine-protein kinase Chk1 2.7.11.1 0.667
2ow3 BIMGlycogen synthase kinase-3 beta 2.7.11.26 0.666
3otu BI43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
4e5f 0N7Polymerase acidic protein / 0.660
1uu3 LY43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.654