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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mf1 29Y Tyrosine-protein kinase ITK/TSK 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mf1 29YTyrosine-protein kinase ITK/TSK 2.7.10.2 0.892
4e5i 0N9Polymerase acidic protein / 0.744
4mf0 29ZTyrosine-protein kinase ITK/TSK 2.7.10.2 0.721
4l7s G7KTyrosine-protein kinase ITK/TSK 2.7.10.2 0.703
4g16 0VMCasein kinase I isoform gamma-3 2.7.11.1 0.676
4kio G5KTyrosine-protein kinase ITK/TSK 2.7.10.2 0.674
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.671
3zbx 6XEHepatocyte growth factor receptor 2.7.10.1 0.671
3zln H0YBcl-2-like protein 1 / 0.671
3zxz KRWHepatocyte growth factor receptor 2.7.10.1 0.669
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.665