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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4m7v RAR Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4m7v RARDihydrofolate reductase / 1.150
3tq8 TOPDihydrofolate reductase / 0.749
4g8z TOPDihydrofolate reductase 1.5.1.3 0.713
1dyr TOPDihydrofolate reductase 1.5.1.3 0.706
2w9h TOPDihydrofolate reductase 1.5.1.3 0.699
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.690
2w9g TOPDihydrofolate reductase 1.5.1.3 0.686
3dat MTXDihydrofolate reductase / 0.684
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.678
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.675
1dra MTXDihydrofolate reductase 1.5.1.3 0.672
1tdr MTXDihydrofolate reductase 1.5.1.3 0.670
3dfr MTXDihydrofolate reductase 1.5.1.3 0.665
3m09 RARDihydrofolate reductase 1.5.1.3 0.665
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.657