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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l2y XXK Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4l2y XXKPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / 1.068
4l23 X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / 0.945
3ls8 AJZPhosphatidylinositol 3-kinase catalytic subunit type 3 2.7.1.137 0.801
4ezj 0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.796
3ibe L64Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.769
4e5l DBHPolymerase acidic protein / 0.696
4ezl 0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.693
3qk0 QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.668
3lj3 WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.667
4ezk 0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.659
4gb9 0WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.659