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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l1x STR Aldo-keto reductase family 1 member C2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4l1x STRAldo-keto reductase family 1 member C2 / 0.998
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
4c49 HCYCorticosteroid-binding globulin / 0.704
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.700
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.685
4ofr DHTAndrogen receptor / 0.685
4bb2 STRCorticosteroid-binding globulin / 0.674
3up0 D7SaceDAF-12 / 0.672
3s79 ASDAromatase 1.14.14.14 0.671
2vdy HCYCorticosteroid-binding globulin / 0.668
2aa6 STRMineralocorticoid receptor / 0.664
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.663
3kyt HC2Nuclear receptor ROR-gamma / 0.662
3mne DEXGlucocorticoid receptor / 0.662
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3mnp DEXGlucocorticoid receptor / 0.656
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.654
1zhw HC2Oxysterol-binding protein homolog 4 / 0.653
1zhy CLROxysterol-binding protein homolog 4 / 0.650