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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ksp 1SU Serine/threonine-protein kinase B-raf 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ksp 1SUSerine/threonine-protein kinase B-raf 2.7.11.1 1.340
4fc0 0T2Serine/threonine-protein kinase B-raf 2.7.11.1 0.841
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.746
3gcv SS6Mitogen-activated protein kinase 14 / 0.713
3gcu R48Mitogen-activated protein kinase 14 / 0.708
3bv2 P38Mitogen-activated protein kinase 14 / 0.700
3bv3 P39Mitogen-activated protein kinase 14 / 0.698
1uwh BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.676
1w83 L11Mitogen-activated protein kinase 14 / 0.672
4aa0 AA0Mitogen-activated protein kinase 14 / 0.663
1wbn L09Mitogen-activated protein kinase 14 / 0.658
1wbv LI3Mitogen-activated protein kinase 14 / 0.652
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.652