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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kik KSA Inhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 1.176
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.859
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.853
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.792
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.769
1xjd STUProtein kinase C theta type 2.7.11.13 0.763
2buj STUSerine/threonine-protein kinase 16 / 0.752
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.746
4e5i 0N9Polymerase acidic protein / 0.744
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.733
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.727
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.720
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.708
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.707
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.698
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.696
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.695
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.694
3zew STUEphrin type-B receptor 4 2.7.10.1 0.691
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.686
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4ftr 5HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.681
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.675
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.673
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.671
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.670
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.666
3t9i 3T9Serine/threonine-protein kinase pim-1 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.658
3kvx FMYMitogen-activated protein kinase 10 2.7.11.24 0.658
4e1z 0MXNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.653
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.652
4k7a DHTAndrogen receptor / 0.652