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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kak 06U Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4kak 06UDihydrofolate reductase 1.5.1.3 1.098
4kd7 9DRDihydrofolate reductase 1.5.1.3 0.772
3eel 53TUncharacterized protein / 0.768
3eej 53RUncharacterized protein / 0.754
3cse N22Uncharacterized protein / 0.751
3k45 51PDihydrofolate reductase 1.5.1.3 0.723
3eek 53SUncharacterized protein / 0.714
4h97 53SDihydrofolate reductase 1.5.1.3 0.699
3qls 55VDihydrofolate reductase 1.5.1.3 0.688
4h95 06UDihydrofolate reductase 1.5.1.3 0.688
3nxo D2BDihydrofolate reductase 1.5.1.3 0.686
3qlr QLRDihydrofolate reductase 1.5.1.3 0.668
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.666
4keb FOLDihydrofolate reductase 1.5.1.3 0.660
3nxt D2EDihydrofolate reductase 1.5.1.3 0.657
3k47 D09Dihydrofolate reductase 1.5.1.3 0.655
3sgy 06WDihydrofolate reductase 1.5.1.3 0.652
3um8 1CYBifunctional dihydrofolate reductase-thymidylate synthase / 0.651
4ddr MMVDihydrofolate reductase 1.5.1.3 0.651