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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4k11 0J9 Proto-oncogene tyrosine-protein kinase Src 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4k11 0J9Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 1.004
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3vs4 VSFTyrosine-protein kinase HCK 2.7.10.2 0.735
1qcf PP1Tyrosine-protein kinase HCK 2.7.10.2 0.732
2zv9 PP2Tyrosine-protein kinase Lyn 2.7.10.2 0.722
4lgg VGGProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.714
2c0t L3GTyrosine-protein kinase HCK 2.7.10.2 0.713
2ivv PP1Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.704
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.698
2c0o L2GTyrosine-protein kinase HCK 2.7.10.2 0.673
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.666
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.664
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
3ncg BK1Calmodulin-domain protein kinase 1, putative / 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4kba 1QMCasein kinase I isoform delta 2.7.11.1 0.655
4jq8 KJ8Epidermal growth factor receptor 2.7.10.1 0.650