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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jq8 KJ8 Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4jq8 KJ8Epidermal growth factor receptor 2.7.10.1 1.194
4jq7 KJQEpidermal growth factor receptor 2.7.10.1 0.972
4jrv KJVEpidermal growth factor receptor 2.7.10.1 0.938
4jr3 KJREpidermal growth factor receptor 2.7.10.1 0.908
2itp AEEEpidermal growth factor receptor 2.7.10.1 0.808
2itt AEEEpidermal growth factor receptor 2.7.10.1 0.772
4e5i 0N9Polymerase acidic protein / 0.744
4i22 IREEpidermal growth factor receptor 2.7.10.1 0.685
4wkq IREEpidermal growth factor receptor 2.7.10.1 0.668
2h8h H8HProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.666
2itz IREEpidermal growth factor receptor 2.7.10.1 0.666
3dne LL1cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
1zz2 B11Mitogen-activated protein kinase 14 / 0.660
2f7e 2EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4f08 1RSTyrosine-protein kinase JAK2 / 0.660
1m17 AQ4Epidermal growth factor receptor 2.7.10.1 0.659
4i23 1C9Epidermal growth factor receptor 2.7.10.1 0.658
2bro DF2Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
3fxu TSUHTH-type transcriptional regulator TsaR / 0.653
4k11 0J9Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.650