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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jpe 1M7 Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4jpe 1M7Beta-secretase 1 3.4.23.46 0.928
4jpc 1M6Beta-secretase 1 3.4.23.46 0.818
4b05 32DBeta-secretase 1 3.4.23.46 0.757
4djx 0KQBeta-secretase 1 3.4.23.46 0.757
4djy 0KRBeta-secretase 1 3.4.23.46 0.754
4djw 0KPBeta-secretase 1 3.4.23.46 0.749
4joo 1M4Beta-secretase 1 3.4.23.46 0.747
4jp9 1M5Beta-secretase 1 3.4.23.46 0.736
4djv 0KMBeta-secretase 1 3.4.23.46 0.727
3l5e BDWBeta-secretase 1 3.4.23.46 0.704
4dju 0KKBeta-secretase 1 3.4.23.46 0.689
4b72 2FBBeta-secretase 1 3.4.23.46 0.687
1owe 675Urokinase-type plasminogen activator 3.4.21.73 0.678
4b0q GMFBeta-secretase 1 3.4.23.46 0.677
4j0z 1H5Beta-secretase 1 3.4.23.46 0.669
2zhf 49UProthrombin 3.4.21.5 0.666
1sqt UI3Urokinase-type plasminogen activator 3.4.21.73 0.665
4b1c 1B1Beta-secretase 1 3.4.23.46 0.663
1lpk CBBCoagulation factor X 3.4.21.6 0.662
1wqv PSMCoagulation factor VII 3.4.21.21 0.662
4fui UI3Urokinase-type plasminogen activator 3.4.21.73 0.661
1ype UIPProthrombin 3.4.21.5 0.660
4baq M4ZProthrombin 3.4.21.5 0.659
2zp0 PI0Coagulation factor VII 3.4.21.21 0.658
4e7r 0NWProthrombin 3.4.21.5 0.652