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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ja8 1K9 Isocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ja8 1K9Isocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 1.396
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.687
2zjf BSUEpoxide hydrolase B / 0.675
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.673
4e5f 0N7Polymerase acidic protein / 0.660
3gi3 B10Mitogen-activated protein kinase 14 / 0.652