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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ixg IXG Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ixg IXGDihydrofolate reductase 1.5.1.3 0.968
4ixf IXFDihydrofolate reductase 1.5.1.3 0.774
3td8 D2RDihydrofolate reductase 1.5.1.3 0.748
3gyf 51PDihydrofolate reductase 1.5.1.3 0.729
3ia4 MTXDihydrofolate reductase / 0.727
3k45 51PDihydrofolate reductase 1.5.1.3 0.726
1dls MTXDihydrofolate reductase 1.5.1.3 0.718
3qlz QLZUncharacterized protein / 0.716
4ixe IXEDihydrofolate reductase 1.5.1.3 0.709
1hfq MOTDihydrofolate reductase 1.5.1.3 0.675
1u70 MTXDihydrofolate reductase 1.5.1.3 0.675
1hfr MOTDihydrofolate reductase 1.5.1.3 0.673
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.673
3l3r OAGDihydrofolate reductase 1.5.1.3 0.672
3eig MTXDihydrofolate reductase 1.5.1.3 0.668
4p68 MTXDihydrofolate reductase / 0.667
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.666
3cse N22Uncharacterized protein / 0.665
1dra MTXDihydrofolate reductase 1.5.1.3 0.664
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.664
4e5f 0N7Polymerase acidic protein / 0.660
3sgy 06WDihydrofolate reductase 1.5.1.3 0.656
3kjs DQ1Bifunctional dihydrofolate reductase-thymidylate synthase / 0.653